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Endocrine Abstracts

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ea0032p644 | Male reproduction | ECE2013

Endocrine disruptors target ATP binding cassette transporters in the blood–testis barrier and impair Leydig cell steroidogenesis

Roelofs Maarke J E , Dankers Anita C A , Piersma Aldert H , Russel Frans G M , van den Berg Martin , Masereeuw Rosalinde , van Duursen Majorie B M

Efflux transporters in the blood–testis barrier (BTB) prevent entry and accumulation of xenobiotics in testis but are also involved in local transport of steroid hormones. Among these are the ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp/ABCB1) and multidrug resistance proteins 1 (MRP1/ABCC1) and 4 (MRP4/ABCC4). Here, we studied the interaction of suggested endocrine disruptors (EDCs) bisphenol A (BPA), tetrabromobisphenol A (TBBPA), bis(...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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